Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. [2] This includes meningitis, plague, cholera, and typhoid fever. Synthesis of Chloramphenicol. Starting from 4-nitroacetanilide, chloramphenicol can be made in high yield in a sequence of eight synthetic steps. INHIBITION OF PROTEIN SYNTHESIS BY CHLORAMPHENICOV By AUSTIN S. WEISBERGER, M.D. School of Medicine, Western Reserve University, and Department Chloramphenicol: Accession Number: DB00446 (APRD00862, EXPT00942) Type: Small. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. We would like to show you a description here but the site won’t allow us. The biosynthesis of chloramphenicol. I. Precursors stimulating the synthesis. J Bacteriol. 1954 Aug; 68 (2):243–251. [PMC free article] KATZ J. G. Fodor Affiliated with Institute of Organic Chemistry Szeged University, J. Toth Affiliated with Institute of Organic Chemistry Szeged University A general route for the synthesis of chloramphenicol, thiamphenicol and fluoramphenicol is described. Chloramphenicol has been synthesized in 45% overall yield. Chloramphenicol Intro An antibiotic produced by Streptomyces venezuelae, an organism first isolated in 1947 from a soil sample collected in Venezuela. www. A protein synthesis inhibitor is a substance that stops or slows the growth or. Chloramphenicol blocks the peptidyl transfer step of elongation on the 50S.