Read Design and synthesis of new antimalarial agents from 4-aminoquinoline on DeepDyve - Instant access to the journals you need! Chemical Biology & Drug Design Vol 78 Issue 1 Abstract;. Synthesis of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine. A series of 4-amino-7-chloroquinoline derivatives were synthesized by the reaction of 4,7-dichloro-quinoline with the corresponding diamine and then with propar 4-Aminoquinoline is a form of aminoquinoline with the amino group at the 4-position of the quinoline. A variety of derivatives of 4-aminoquinoline are antimalarial. Read Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline–triazine conjugates on DeepDyve - Instant access to the journals you need! Highlights • New hybrids of 4-aminoquinoline and pyrimidine were synthesized efficaciously. • nM range antiplasmodial activity. • Activity against both CQ S and. In an attempt to augment the efficacy of 7-chloro 4-aminoquinoline analogs and also to overcome resistance to antimalarial agents, we synthesized three. Greener synthesis of 4-aminoquinoline-2-ones was achieved by intramolecular cyclization of 2-cyanophenylamide derivatives using biodegradable and recyclable choline. Synthesis and Antimalarial Activities of Cyclen 4-Aminoquinoline Analogs. M. O. Faruk Khan, 1, † Mark S. Levi, 1, ‡ Babu L. Tekwani, 2 Shabana I. Khan, 2 Eiichi. 1. Chem Biol Drug Des. 2011 Jul;78(1):124-36. doi: 10.1111/j.1747-0285.2011.01115.x. Epub 2011 Apr 27. Synthesis of 4-aminoquinoline-1,2,3-triazole and 4.