In neuroscience, a silent synapse is an excitatory glutamatergic synapse whose postsynaptic membrane contains NMDA-type glutamate receptors but no AMPA-type glutamate. Definitions of Silent synapse, synonyms, antonyms, derivatives of Silent synapse, analogical dictionary of Silent synapse (English) AMPA-silent synapses in brain development and pathology. In favour of the hypothesis that AMPA-silent. The two destinies of the AMPA-silent synapse. Silent synapse refers to a synaptic contact between two neurons where a presynaptic action potential fails to evoke a detectable postsynaptic signal. Abstract: Purpose: Studies using external field stimulation showed that the failure rate of NMDAR EPSCs is much lower than that of AMPAR EPSCs. Read P-C2-06 Critical test of silent synapse hypothesis on DeepDyve - Instant access to the journals you need! Silent synapses abound in the young brain, representing an early step in the pathway of experience-dependent synaptic development. Discovered amidst the debate over. Talk:Silent synapse. The Whispering Synapse Hypothesis holds that this reduced glutamate concentration interacts effectively only with the NMDA receptors. From Wikipedia, the free encyclopedia. In neuroscience, a silent synapse is an excitatory glutamatergic synapse whose postsynaptic membrane contains NMDA-type. Activation of silent and weak synapses by cAMP. Silent synapse activation did not correlate. presynaptic terminals to test this hypothesis.