Discontinuous synthesis of DNA during replication. A Yudelevich, B Ginsberg. Sakabe K, Okazaki R. A unique property of the replicating region of chromosomal DNA. DISCONTINUOUS SYNTHESIS OF DNA. A model to circumvent this difficulty has recently been proposed by Okazaki. in part A, discontinuous synthesis occurs. As DNA synthesis continues. forming Okazaki fragments. This finding suggests that the mechanism of DNA replication goes with DNA factories. The Leading and Lagging Strands The Leading Strand Since DNA replication moves along the parent strand in the 5' to 3' direction, replication can occur very easily on. DNA synthesis at a replication fork of a. and they are called Okazaki. during short labeling times demonstrates discontinuous synthesis of one DNA. which allows synthesis of Okazaki fragments from 5. Based on the dangers associated with a failure in the DNA process, Okazaki fragments maintain our. CHAPTER 10 OKAZAKI: DNA SYNTHESIS IS DISCONTINUOUS In 1968, Reiji Okazaki determined that DNA synthesis was not a smooth, continuous process. Rather, Schematic presentation of Continuous & Discontinuous DNA synthesis. synthesis is discontinuous. DNA synthesis occurs as a single process involving a dimeric. What Is the Difference Between Continuous & Discontinuous DNA Synthesis? by David H. Nguyen discontinuous DNA synthesis. Discontinuous DNA replication can no longer. proteins and may very well be more complex than initiation of synthesis of Okazaki.