Definition of de novo in the AudioEnglish.org Dictionary. Meaning of de novo. What does de novo mean? Proper usage and pronunciation (in phonetic transcription) of. The term ‘’de novo’’ is often italicized when written to indicate. ’’de novo’’ synthesis of a complex. (De morgan campbell) | Next (De novo. trial de novo. n. a form of appeal in which the appeals court holds a trial as if no prior trial had been held. A trial de novo is common on appeals from small claims. De Novo [Latin, Anew.] A second time; afresh. A trial or a hearing that is ordered by an appellate court that has reviewed the record of a hearing in a lower court. De novo synthesis also refers to DNA replication. Primase is an RNA polymerase, and it can add a primer to an existing strand awaiting replication. De novo synthesis of complex molecules from simple molecules in biochemistry;. For example, growth de novo means growth of newly started companies. de no·vo (dĭ nō′vō, dā) adv. & adj. Over again, anew. [Latin dē novō.] de novo (diː ˈnəʊvəʊ) adv. from the beginning; anew. de no•vo In recent years, the basic processes of plant nucleotide de novo synthesis have been analyzed in some detail (Giermann et al., 2002; Moffatt and Ashihara, 2002; Boldt. Seen and Heard. What made you want to look up de novo? Please tell us where you read or heard it (including the quote, if possible). De novo mRNA synthesis is required for both consolidation and reconsolidation of fear memories in the amygdala.